Document Detail


The therapeutic potential of lactoferrin.
MedLine Citation:
PMID:  12720494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lactoferrin (Lf), a natural defence iron-binding protein, is present in exocrine secretions that are commonly exposed to normal flora: milk, tears, nasal exudate, saliva, bronchial mucus, gastrointestinal fluids, cervicovaginal mucus and seminal fluid. Additionally, Lf is produced in polymorphonuclear leukocytes and is deposited by these circulating cells in septic sites. A principal function of Lf is that of scavenging non-protein-bound iron in body fluids and inflamed areas so as to suppress free radical-mediated damage and decrease accessibility of the metal to invading bacterial, fungal and neoplastic cells. Adequate sources of bovine and recombinant human Lf are now available for development of commercial applications. Among the latter are use of Lf in food preservation, fish farming, infant milk formula and oral hygiene. Other readily accessible body compartments for Lf administration include skin, throat and small intestine. Further research is needed for possible medicinal use in colon and systemic tissues. Although Lf is a natural product and should be highly biocompatible, possible hazards have been documented.
Authors:
Eugene D Weinberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  12     ISSN:  1354-3784     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-04-30     Completed Date:  2003-08-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  841-51     Citation Subset:  IM    
Affiliation:
Department of Biology and Programme in Medical Sciences, Indiana University, Bloomington, Indiana, USA. eweinber@indiana.edu
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / adverse effects,  biosynthesis,  therapeutic use
Anti-Infective Agents / adverse effects,  therapeutic use
Antineoplastic Agents / adverse effects,  therapeutic use
Antioxidants / adverse effects,  therapeutic use
Body Fluids / metabolism
Humans
Lactoferrin / adverse effects,  biosynthesis*,  therapeutic use*
Peptide Fragments / therapeutic use
Recombinant Proteins / adverse effects,  biosynthesis,  therapeutic use
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Anti-Infective Agents; 0/Antineoplastic Agents; 0/Antioxidants; 0/Lactoferrin; 0/Peptide Fragments; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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