Document Detail


The therapeutic potential of G-CSF in pressure overload induced ventricular reconstruction and heart failure in mice.
MedLine Citation:
PMID:  21431359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In animal models of clinical entities causative of severe right and left ventricular (LV) pressure overload hypertrophy, increased density of the cellular microtubule network, through viscous loading of active myofilaments, causes contractile dysfunction that is normalized by microtubule depolymerization. In this study, 86 male mice were divided into seven groups. The transverse ascending aorta constriction (TAC) in six groups were performed in order to make heart failure model. Mice in each group were injected with G-CSF or/and telmisartan subcutaneously at different time respectively. Results showed that reduction in left ventricular volume and improved function persisted at 2 week, but recurrent dilatation at 4 weeks was associated with a loss of functional improvement. Compared with PBS group, the expression of VEGF protein and HIF-1 mRNA were significantly higher in mice injected with G-CSF or/and telmisartan (P<0.05). The expression of p53 mRNA, myocardial fibrosis and mortality were significantly lower in mice injected with G-CSF or/and telmisartan (P<0.05). It could be concluded that G-CSF can delay the progression of pressure overload induced ventricular reconstruction and heart failure in mice.
Authors:
Ji Ming Li; Zhi Feng Yao; Yun Zeng Zou; Jun Bo Ge; Ai Li Guan; Jian Wu; Shou Ling Mi; Yan Yan Liang; Zhen Ma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-23
Journal Detail:
Title:  Molecular biology reports     Volume:  39     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-22     Completed Date:  2012-03-21     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzimidazoles / pharmacology,  therapeutic use
Benzoates / pharmacology,  therapeutic use
Blotting, Western
Carotid Arteries / surgery
Constriction
DNA Primers / genetics
Echocardiography
Granulocyte Colony-Stimulating Factor / pharmacology,  therapeutic use*
Heart Failure / etiology*,  prevention & control*
Hypertension / complications*
Hypertrophy, Left Ventricular / complications,  drug therapy*,  etiology*
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Male
Mice
Mice, Inbred C57BL
Microtubules / pathology
Reverse Transcriptase Polymerase Chain Reaction
Vascular Endothelial Growth Factor A / metabolism
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Benzoates; 0/DNA Primers; 0/Hif1a protein, mouse; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Vascular Endothelial Growth Factor A; 143011-72-7/Granulocyte Colony-Stimulating Factor; U5SYW473RQ/telmisartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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