Document Detail


The therapeutic journey of benzimidazoles: A review.
MedLine Citation:
PMID:  23031649     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton pump inhibitors, antihypertensives, anticoagulants, immunomodulators, hormone modulators, CNS stimulants as well as depressants, lipid level modulators, antidiabetics, etc. has made it an indispensable anchor for development of new therapeutic agents. Varied substitutents around the benzimidazole nucleus have provided a wide spectrum of biological activities. Importance of this nucleus in some activities like, Angiotensin I (AT(1)) receptor antagonism and proton-pump inhibition is reviewed separately in literature. Even some very short reviews on biological importance of this nucleus are also known in literature. However, owing to fast development of new drugs possessing benzimidazole nucleus many research reports are generated in short span of time. So, there is a need to couple the latest information with the earlier information to understand the current status of benzimidazole nucleus in medicinal chemistry research. In the present review, various derivatives of benzimidazole with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimidazole derived compounds for each activity. This discussion will further help in the development of novel benzimidazole compounds.
Authors:
Yogita Bansal; Om Silakari
Related Documents :
20141879 - Fragrance material review on phytol.
20047359 - Book reviews.
21375219 - Cecal volvulus and mucocele of the appendix.
20141889 - Fragrance material review on 2-methyl-3-buten-2-ol.
19185329 - Withdrawn: book review.
22815129 - Oxygen saturation in pulse oximetry in hemoglobin anomalies.
17187279 - Arthroscopic treatment for synovial chondromatosis of the subacromial bursa: a case rep...
16226969 - Horner syndrome due to first rib fracture after major thoracic trauma.
3524839 - Prognostic signs in fetal hydrocephalus.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-17
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  -     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Molecular Modelling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of the side chain stereochemistry in the ?-glucosidase inhibitory activity of kotalanol, a pote...
Next Document:  Proteomic analysis reveals the diversity and complexity of membrane proteins in chickpea (Cicer arie...