Document Detail


The therapeutic effect of L-carnitine in patients with exercise-induced stable angina: a controlled study.
MedLine Citation:
PMID:  1794297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An investigation on the therapeutic effect of L-carnitine was performed at three different centres and included two hundred patients, 40 to 65 years of age, with exercise-induced stable angina. In one hundred randomly selected patients the drug was administered orally in daily doses of 2 g in addition to the already instituted therapy, and the effect studied over a 6-month period. Compared with the control group, these patients showed a significant reduction in the number of premature ventricular contractions (PVC) at rest, as well as an increased tolerance during ergometric cycle exercise as demonstrated by an increased maximal cardiac frequency, increased maximal systolic arterial blood pressure and therefore also increased double cardiac product and reduced ST-segment depression during maximal effort. This was accompanied by improvement in cardiac function and resultant performance, as shown by an increase in the number of patients belonging to class I of the NYHA classification and a reduction in the consumption of cardioactive drugs. Laboratory analysis showed an improvement in plasma lipid levels. The authors conclude, after having discussed the particular metabolic mechanisms, that L-carnitine undoubtedly represents an interesting therapeutic drug for patients with exercise-induced stable angina.
Authors:
L Cacciatore; R Cerio; M Ciarimboli; M Cocozza; V Coto; A D'Alessandro; L D'Alessandro; G Grattarola; L Imparato; M Lingetti
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  17     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-03     Completed Date:  1992-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  225-35     Citation Subset:  IM    
Affiliation:
IV Internal Medicine Department, II Medical School, University of Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / drug therapy*
Blood Pressure / drug effects
Carnitine / therapeutic use*
Diltiazem / administration & dosage
Female
Humans
Male
Middle Aged
Nifedipine / administration & dosage
Nitroglycerin / administration & dosage
Physical Exertion
Ventricular Function / drug effects
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine; 42399-41-7/Diltiazem; 541-15-1/Carnitine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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