| A theory for water and macromolecular transport in the pulmo-nary artery with a detailed compariuson to the aorta. | |
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MedLine Citation:
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PMID: 22198178 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The pulmonary artery (PA) wall, which has much higher hydraulic conductivity and albumin void space and ~1/6 the normal transmural pressure of systemic arteries (e.g, aorta, ca¬rotid arteries), is rarely atherosclerotic, except under pulmonary hypertension. This paper constructs a detailed, two-dimensional, wall-structure-based filtration and macromolecular transport model for the PA in order to investigate differences in prelesion transport processes between the disease-susceptible aorta and the relatively resistant PA. The PA and aorta models are similar in wall structure, but very different in parameter values, many of which have been measured (and therefore modified) since Huang et al's (1994) original aorta model. Both PA and aortic model simulations fit experimental data on transwall LDL concentration profiles and on the growth of isolated endothelial (HRP) tracer spots with circulation time very well. They reveal that lipid entering the aorta attains a much higher intima than media concentration, but distributes better between these regions in the PA than aorta and that tracer in both regions contributes to observed tracer spots. Solutions show why both the overall transmural water flow and spot growth rates are similar in these vessels despite very different material transport parameters. Since early lipid accumulation occurs in the subendothelial intima and since (matrix binding) reaction kinetics depend on reactant concentrations, the lower intima lipid concentrations in the PA vs aorta likely lead to slower accumulation of bound lipid in the PA. These findings may be relevant to understanding the different atherosusceptibilities of these vessels. |
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Authors:
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Zhongqing Zeng; Kung-Ming Jan; David S Rumschitzki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1City College of the City University of New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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