Document Detail


A theory for water and macromolecular transport in the pulmonary artery wall with a detailed comparison to the aorta.
MedLine Citation:
PMID:  22198178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pulmonary artery (PA) wall, which has much higher hydraulic conductivity and albumin void space and approximately one-sixth the normal transmural pressure of systemic arteries (e.g, aorta, carotid arteries), is rarely atherosclerotic, except under pulmonary hypertension. This study constructs a detailed, two-dimensional, wall-structure-based filtration and macromolecular transport model for the PA to investigate differences in prelesion transport processes between the disease-susceptible aorta and the relatively resistant PA. The PA and aorta models are similar in wall structure, but very different in parameter values, many of which have been measured (and therefore modified) since the original aorta model of Huang et al. (23). Both PA and aortic model simulations fit experimental data on transwall LDL concentration profiles and on the growth of isolated endothelial (horseradish peroxidase) tracer spots with circulation time very well. They reveal that lipid entering the aorta attains a much higher intima than media concentration but distributes better between these regions in the PA than aorta and that tracer in both regions contributes to observed tracer spots. Solutions show why both the overall transmural water flow and spot growth rates are similar in these vessels despite very different material transport parameters. Since early lipid accumulation occurs in the subendothelial intima and since (matrix binding) reaction kinetics depend on reactant concentrations, the lower intima lipid concentrations in the PA vs. aorta likely lead to slower accumulation of bound lipid in the PA. These findings may be relevant to understanding the different atherosusceptibilities of these vessels.
Authors:
Zhongqing Zeng; Kung-Ming Jan; David S Rumschitzki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-12-23
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  302     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-05-30     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1683-99     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, City College of City University of New York, New York, New York 10031, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Aorta / metabolism
Biological Transport, Active / physiology*
Endothelial Cells / metabolism
Horseradish Peroxidase
Humans
Kinetics
Lipid Metabolism / physiology
Lipoproteins, LDL / metabolism
Liposomes
Macromolecular Substances / metabolism
Models, Statistical
Myocardium / metabolism*
Pulmonary Artery / metabolism*
Water / metabolism*
Grant Support
ID/Acronym/Agency:
5-RO1-HL06738/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Liposomes; 0/Macromolecular Substances; 7732-18-5/Water; EC 1.11.1.-/Horseradish Peroxidase
Comments/Corrections

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