| The theory and relevance of continuous culture. | |
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MedLine Citation:
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PMID: 3884567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Batch cultures of micro-organisms which utilize typical laboratory media, generally result in rapidly dividing cultures (generation times less than 1 h). These are atypical of those found in natural environments. The continuous culture of micro-organisms allows either specific-growth-rate to be controlled, whilst maintaining the cells in a constant physical and chemical environment or a constant specific-growth-rate to be maintained whilst physico-chemical parameters of growth such as pH, temperature or nutrient availability are varied. Continuous culture therefore offers the prospect of in-vitro culture of micro-organisms in physiological states relevant to their natural habitats. This article introduces the concepts of continuous culture and discusses their relevance towards in-vitro models of infection and of antibiotic dosing. |
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Authors:
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P Gilbert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 15 Suppl A ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-05-14 Completed Date: 1985-05-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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metabolism,
pharmacology Bacteria / growth & development* Kinetics Microbial Sensitivity Tests Microbiological Techniques* Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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