Document Detail

A theory of germinal center B cell selection, division, and exit.
MedLine Citation:
PMID:  22840406     Owner:  NLM     Status:  MEDLINE    
High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell migration patterns, asymmetric cell divisions, and cell-cell interaction characteristics, used here to develop a theory of germinal center B cell selection, division, and exit (the LEDA model). According to this model, B cells selected by T follicular helper cells on the basis of successful antigen processing always return to the dark zone for asymmetric division, and acquired antigen is inherited by one daughter cell only. Antigen-retaining B cells differentiate to plasma cells and leave the germinal center through the dark zone. This theory has implications for the functioning of germinal centers because compared to previous models, high-affinity antibodies appear one day earlier and the amount of derived plasma cells is considerably larger.
Michael Meyer-Hermann; Elodie Mohr; Nadége Pelletier; Yang Zhang; Gabriel D Victora; Kai-Michael Toellner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-28
Journal Detail:
Title:  Cell reports     Volume:  2     ISSN:  2211-1247     ISO Abbreviation:  Cell Rep     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2013-03-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101573691     Medline TA:  Cell Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Antibody Affinity / immunology
B-Lymphocytes / cytology*,  metabolism,  physiology*
Cell Differentiation / genetics,  immunology
Cell Division / genetics,  physiology*
Cell Movement / genetics,  immunology
Chemotaxis, Leukocyte / genetics,  physiology
Germinal Center / cytology*,  immunology
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Models, Biological
Models, Theoretical*
Grant Support
G1001390//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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