Document Detail

A theory of carcinogenesis based on an analysis of the effects of carcinogens.
MedLine Citation:
PMID:  3320696     Owner:  NLM     Status:  MEDLINE    
Carcinogenic stimuli appear to act on target cells (and their daughters) by one or more of three mechanisms. The first is by oxidation of membrane component molecules on the extracellular surfaces of their plasma membranes. The second is by chronic and continuous impingement of electrons on the extracellular surfaces of their plasma membranes and the third is by relocation of predominantly basic molecules to the cytoplasmic surfaces of their plasma membranes. This latter effect in turn causes electrostatic attraction of image charged acidic molecules to the extracellular surfaces to balance the transmembrane charge of the target cells. Each of the above mechanisms results in a condition of increased electronegativity of the extracellular surfaces of plasma membranes of the target cells and their daughters. A theory of transformation is advanced based on the above related modes of action and it is used to explain some previously unexplainable properties of tumors.
J A Beech
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  24     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-02-04     Completed Date:  1988-02-04     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  265-86     Citation Subset:  IM    
University of Miami, Department of Epidemiology and Public Health, FL 33177-1411.
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MeSH Terms
Carcinogens / toxicity*
Cell Membrane / physiology
Cell Transformation, Neoplastic / etiology*,  ultrastructure
Membrane Potentials
Reg. No./Substance:

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