| A theoretical model for the margination of particles within blood vessels. | |
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MedLine Citation:
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PMID: 15771271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The margination of a particle circulating in the blood stream has been analyzed. The contribution of buoyancy, hemodynamic forces, van der Waals, electrostatic and steric interactions between the circulating particle and the endothelium lining the vasculature has been considered. For practical applications, the contribution of buoyancy, hemodynamic forces and van der Waals interactions should be only taken into account, whilst the effect of electrostatic and steric repulsion becomes important only at very short distances from the endothelium (1-10 nm). The margination speed and the time for margination t(s) have been estimated as a function of the density of the particle relative to blood delta rho, the Hamaker constant A and radius R of the particle. A critical radius Rc exists for which the margination time t(s) has a maximum, which is influenced by both delta rho and A: the critical radius decreases as the relative density increases and the Hamaker constant decreases. Therefore, particles used for drug delivery should have a radius smaller than the critical value (in the range of 100 nm) to facilitate margination and interaction with the endothelium. While particles used as nanoharvesting agents in proteomics or genomics analysis should have a radius close to the critical value to minimize margination and increase their circulation time. |
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Authors:
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P Decuzzi; S Lee; B Bhushan; M Ferrari |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 33 ISSN: 0090-6964 ISO Abbreviation: Ann Biomed Eng Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-03-17 Completed Date: 2005-07-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 179-90 Citation Subset: IM |
Affiliation:
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Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari 70125, Italy. p.decuzzi@poliba.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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physiology Blood Physiological Phenomena* Blood Pressure / physiology Blood Vessels / physiology* Blood Viscosity Computer Simulation Drug Carriers / administration & dosage, chemistry* Drug Therapy, Computer-Assisted / methods* Microspheres Models, Cardiovascular* Motion Nanotubes / chemistry* Particle Size Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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