| A theoretical model of a compliant arterial stenosis. | |
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MedLine Citation:
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PMID: 3970228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent clinical and experimental evidence indicates that coronary artery stenoses may rapidly change their size and shape in response to alterations in vasomotor tone and intraluminal pressure. This theoretical study models a partially compliant arterial stenosis to examine the hemodynamic impact of these alterations. In rigid vessels, a 98% reduction in luminal area would predictably produce subendocardial ischemia in the resting state. In contrast, stenoses, with part of the arterial wall normal by the underlying plaque, responded to vasoconstriction and to changes in intraluminal pressure. With part of the arterial wall normal by the plaque, both vasoconstriction and decreases in intraluminal pressure could increase the hemodynamic severity of the stenosis. Further, the more eccentrically positioned the underlying plaque was, the greater the effects of vasoconstriction and intraluminal pressure on stenotic severity. Thus the morphological configuration of the plaque and the normal wall segment in the stenosis appear to be important determinants of the hemodynamic response of the stenosis to vasoconstriction and blood pressure changes. In turn, these changes in stenotic severity can greatly influence flow through the vessel. |
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Authors:
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W P Santamore; A A Bove |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 248 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-03-15 Completed Date: 1985-03-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H274-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
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complications,
physiopathology* Compliance Constriction, Pathologic Ischemia / etiology Models, Cardiovascular* Regional Blood Flow Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL-01026/HL/NHLBI NIH HHS; HL-31644/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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