Document Detail

The theoretical basis for using apnoeic oxygenation via the non-ventilated lung during one-lung ventilation to delay the onset of arterial hypoxaemia.
MedLine Citation:
PMID:  16398387     Owner:  NLM     Status:  MEDLINE    
At the time one-lung ventilation is initiated, nitrogen from the atmosphere may enter the non-ventilated lung via a double-lumen tube connector that has been left open to air, even momentarily. Ongoing oxygen uptake from the non-ventilated lung raises the partial pressure of nitrogen. This should lead to activation of hypoxic pulmonary vasoconstriction and a reduction in intra-pulmonary shunting. However, in spite of this, some patients still become hypoxaemic. In such cases, it may be advantageous to have excluded nitrogen from the non-ventilated lung by connecting it to an oxygen source at ambient pressure. Ongoing apnoeic oxygenation, while the airways are patent, and as the lung collapses, should delay the onset of arterial desaturation. In this paper we review the theoretical basis for apnoeic oxygenation during one-lung ventilation, and in particular on oxygen uptake by the non-ventilated lung prior to and during its subsequent collapse.
J Pfitzner; L Pfitzner
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  33     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  794-800     Citation Subset:  IM    
Department of Anaesthesia, The Queen Elizabeth Hospital, Woodville, South Australia.
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MeSH Terms
Anesthesia, Inhalation / methods
Anoxia / prevention & control*
Blood Gas Analysis
Nitrous Oxide / administration & dosage*
Oxygen / blood,  therapeutic use*
Positive-Pressure Respiration / methods*
Pulmonary Ventilation
Respiratory Mechanics
Sensitivity and Specificity
Tidal Volume
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 7782-44-7/Oxygen
Erratum In:
Anaesth Intensive Care. 2006 Feb;34(1):114

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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