Document Detail


The theft of host heme by Gram-positive pathogenic bacteria.
MedLine Citation:
PMID:  21725569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The element iron is essential for bacteria and plays a key role in the virulence and pathology of bacterial diseases. The largest reservoir of iron within the human body is in protoporphyrin IX, the compound commonly referred to as heme and bound by hemoglobin. For many years, the study of heme uptake in bacteria was restricted to Gram-negative organisms. However, recent studies have shed light on how bacteria containing a thick peptidoglycan, such as Gram-positive bacteria, acquire and transport heme. This review summarizes old and new research covering the acquisition, transport, and utilization of heme in Gram-positive bacterial pathogens.
Authors:
Christopher L Nobles; Anthony W Maresso
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-07-04
Journal Detail:
Title:  Metallomics : integrated biometal science     Volume:  3     ISSN:  1756-591X     ISO Abbreviation:  Metallomics     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-03     Completed Date:  2012-01-11     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101478346     Medline TA:  Metallomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  788-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / chemistry,  metabolism*
Gram-Positive Bacteria / metabolism*
Heme / metabolism*
Host-Pathogen Interactions*
Humans
Iron / metabolism
Protein Structure, Tertiary
Grant Support
ID/Acronym/Agency:
AI079165/AI/NIAID NIH HHS; K22 AI079165/AI/NIAID NIH HHS; R21 AI088329/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 42VZT0U6YR/Heme; E1UOL152H7/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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