Document Detail

A tetranucleotide repeat mouse minisatellite displaying substantial somatic instability during early preimplantation development.
MedLine Citation:
PMID:  8406443     Owner:  NLM     Status:  MEDLINE    
The highly variable mouse minisatellite Hm-2 is located on chromosome 9 and consists of GGCA tetranucleotide repeats with alleles containing up to 5000 repeat units. This locus is unstable with a germline mutation rate to new length alleles of at least 3.6% per gamete. Hm-2 also shows substantial somatic instability, producing mutational mosaicism detectable in 20% of adult mice. Analysis of allele dosage in mice carrying somatic mutations, plus studies of mosaicism in mouse embryos and extraembryonic tissues, suggests that somatic mutant alleles preferentially arise during preimplantation development and particularly during the first two cell divisions after fertilization.
M Gibbs; A Collick; R G Kelly; A J Jeffreys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  17     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-22     Completed Date:  1993-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  IM    
Department of Genetics, University of Leicester, England.
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MeSH Terms
Base Sequence
Chromosome Mapping
DNA, Satellite / genetics*
Embryonic and Fetal Development / genetics*
Mice, Inbred Strains / embryology,  genetics*
Molecular Sequence Data
Mosaicism / genetics
Organ Specificity
Repetitive Sequences, Nucleic Acid*
Reg. No./Substance:
0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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