| Δ(9) -tetrahydrocannabinol and its major metabolite Δ(9) -tetrahydrocannabinol-11-oic acid as 15-lipoxygenase inhibitors. | |
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MedLine Citation:
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PMID: 20891010 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein, a major causal factor for atherosclerosis. Δ(9) -Tetrahydrocannabinol (Δ(9) -THC), a major component of marijuana, has suggested to suppress atherosclerosis. Although Δ(9) -THC seems to be attractive for the prevention of atherosclerosis, there is no information about whether or not 15-LOX isoform can be inhibited by Δ(9) -THC. In the present study, Δ(9) -THC was found to be a direct inhibitor for 15-LOX with an IC(50) (50% inhibition concentration) value of 2.42 μM. Furthermore, Δ(9) -THC-11-oic acid, a major and nonpsychoactive metabolite of Δ(9) -THC, but not another Δ(9) -THC metabolite 11-OH-Δ(9) -THC (psychoactive), was revealed to inhibit 15-LOX. Taken together, it is suggested that Δ(9) -THC can abrogate atherosclerosis via direct inhibition of 15-LOX, and that Δ(9) -THC-11-oic acid is shown to be an "active metabolite" of Δ(9) -THC in this case. © 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:1206-1211, 2011. |
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Authors:
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Shuso Takeda; Rongrong Jiang; Hironori Aramaki; Masumi Imoto; Akihisa Toda; Reiko Eyanagi; Toshiaki Amamoto; Ikuo Yamamoto; Kazuhito Watanabe |
Publication Detail:
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Type: Journal Article Date: 2010-10-01 |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 100 ISSN: 1520-6017 ISO Abbreviation: J Pharm Sci Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1206-11 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan; Organization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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