| The transmission/disequilibrium test and parental-genotype reconstruction for X-chromosomal markers. | |
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MedLine Citation:
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PMID: 10712229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Family-based association methods have recently been introduced that allow testing for linkage in the presence of linkage disequilibrium between a marker and a disease even if there is only incomplete parental-marker information. No such tests are currently available for X-linked markers. This report fills this methodological gap by presenting the X-linked sibling transmission/disequilibrium test (XS-TDT) and the X-linked reconstruction-combination transmission/disequilibrium test (XRC-TDT). As do their autosomal counterparts (S-TDT and RC-TDT), these tests make no assumption about the mode of inheritance of the disease and the ascertainment of the sample. They protect against spurious association due to population stratification. The two tests were compared by simulations, which show that (1) the X-linked RC-TDT is, in general, considerably more powerful than the X-linked S-TDT and (2) the lack of parental-genotype information can be offset by the typing of a sufficient number of sibling controls. A freely available SAS implementation of these tests allows the calculation of exact P values. |
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Authors:
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S Horvath; N M Laird; M Knapp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of human genetics Volume: 66 ISSN: 0002-9297 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-04-20 Completed Date: 2000-04-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1161-7 Citation Subset: IM |
Affiliation:
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Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, D-53105 Bonn, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Chromosome Mapping / methods*, statistics & numerical data Computer Simulation Female Gene Frequency / genetics Genetic Markers / genetics Genotype Humans Linkage Disequilibrium / genetics* Male Parents* Probability X Chromosome / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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