| A test of the lipostat theory in a seasonal (ovine) model under natural conditions reveals a close relationship between adiposity and melanin concentrating hormone expression. | |
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MedLine Citation:
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PMID: 19179037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was undertaken in Corriedale ewes to test the lipostat theory using data obtained from a model of seasonal change in food intake and body composition. The theory predicts adipose-derived factors signal to the brain and vice versa, to maintain homeostasis. It is held that leptin acts on cells in the brain to regulate food intake and energy expenditure, through "first order" neurons in the arcuate nucleus (ARC). These cells are thought to receive information that is relayed to "second order" neurons, to regulate food intake and other functions. In this study, groups (n=4-5) of ovariectomized ewes were maintained under natural conditions and sampled at various points across the year. Food intake, body composition and indices of metabolic function were measured prior to collection of brains for in situ hybridization analysis. Expression of genes encoding for neuropeptide Y (NPY), pro-opiomelanocortin (POMC), orexin (ORX), melanin concentrating hormone (MCH) and leptin receptor (ObRb) was quantified. NPY gene expression was high when food intake was also high but, across the year, changes in NPY and POMC gene expression did not correspond predictably to plasma leptin levels or leptin receptor gene expression. Negative correlation was found between adiposity (omental and whole body fat) and gene expression of MCH and ORX, suggesting that changes in expression of genes for "second order" orexigenic peptides are closely linked to changes of metabolic state, even when similar relationships cannot be shown for expression of genes in "first order" neurons. These data provide support for the lipostat theory. |
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Authors:
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Chantacha Anukulkitch; Alexandra Rao; Frank R Dunshea; Iain J Clarke |
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Publication Detail:
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Type: Journal Article Date: 2009-01-19 |
Journal Detail:
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Title: Domestic animal endocrinology Volume: 36 ISSN: 1879-0054 ISO Abbreviation: Domest. Anim. Endocrinol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505191 Medline TA: Domest Anim Endocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 138-51 Citation Subset: IM |
Affiliation:
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Dept. of Physiology, Building 13F, Monash University, Clayton, VIC 3800, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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genetics,
physiology* Animals Appetite / genetics Blood Glucose / metabolism Brain / physiology Eating Energy Metabolism Fatty Acids, Nonesterified / blood Female Gene Expression Regulation Hypothalamic Hormones / biosynthesis*, genetics In Situ Hybridization / veterinary Insulin / blood Intracellular Signaling Peptides and Proteins / genetics Leptin / blood Melanins / biosynthesis*, genetics Neuropeptide Y / biosynthesis, genetics Neuropeptides / biosynthesis, genetics Pituitary Hormones / biosynthesis*, genetics Pro-Opiomelanocortin / biosynthesis, genetics Receptors, Leptin / biosynthesis, genetics Seasons Sheep / genetics, metabolism, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Hypothalamic Hormones; 0/Intracellular Signaling Peptides and Proteins; 0/Leptin; 0/Melanins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Pituitary Hormones; 0/Receptors, Leptin; 0/orexins; 11061-68-0/Insulin; 66796-54-1/Pro-Opiomelanocortin; 67382-96-1/melanin-concentrating hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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