| A test hierarchy for anti-bronchoconstrictory lipoxygenase inhibitors: in vitro and in vivo experimental tests. | |
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MedLine Citation:
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PMID: 3116832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A test hierarchy for potential antiasthmatic lipoxygenase inhibitors was developed which includes besides molecular and cellular test systems, the arachidonic acid-(AA)-induced contraction of lung strips and ovalbumin-induced bronchoconstriction of sensitized guinea pigs. Nordihydroguaiaretic acid, butylated hydroxyanisole, benoxaprofen, BW 755C, salicylhydroxamic acid, FLM 5011 and other substances inhibit to a different extent the AA-induced contraction of lung strips and show anti-bronchoconstrictory activities in the ovalbumin-sensitized guinea pig. |
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Authors:
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J Slapke; G Becher; T Schewe; H Kühn; W Förster; J Winkler |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergologia et immunopathologia Volume: 15 ISSN: 0301-0546 ISO Abbreviation: Allergol Immunopathol (Madr) Publication Date: 1987 May-Jun |
Date Detail:
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Created Date: 1987-11-02 Completed Date: 1987-11-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370073 Medline TA: Allergol Immunopathol (Madr) Country: SPAIN |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Research Institute for Lung Diseases and Tuberculosis, Martin Luther University, Berlin & Halle, German Democratic Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acids / pharmacology Asthma / drug therapy Bronchial Provocation Tests Guinea Pigs Lipoxygenase Inhibitors* Lung / drug effects Male |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Lipoxygenase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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