Document Detail

A test hierarchy for anti-bronchoconstrictory lipoxygenase inhibitors: in vitro and in vivo experimental tests.
MedLine Citation:
PMID:  3116832     Owner:  NLM     Status:  MEDLINE    
A test hierarchy for potential antiasthmatic lipoxygenase inhibitors was developed which includes besides molecular and cellular test systems, the arachidonic acid-(AA)-induced contraction of lung strips and ovalbumin-induced bronchoconstriction of sensitized guinea pigs. Nordihydroguaiaretic acid, butylated hydroxyanisole, benoxaprofen, BW 755C, salicylhydroxamic acid, FLM 5011 and other substances inhibit to a different extent the AA-induced contraction of lung strips and show anti-bronchoconstrictory activities in the ovalbumin-sensitized guinea pig.
J Slapke; G Becher; T Schewe; H Kühn; W Förster; J Winkler
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  15     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1987 May-Jun
Date Detail:
Created Date:  1987-11-02     Completed Date:  1987-11-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Research Institute for Lung Diseases and Tuberculosis, Martin Luther University, Berlin & Halle, German Democratic Republic.
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MeSH Terms
Arachidonic Acids / pharmacology
Asthma / drug therapy
Bronchial Provocation Tests
Guinea Pigs
Lipoxygenase Inhibitors*
Lung / drug effects
Reg. No./Substance:
0/Arachidonic Acids; 0/Lipoxygenase Inhibitors

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