| A test of Fisher's theory of dominance. | |
| | |
MedLine Citation:
|
PMID: 1763055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
One of the first patterns noticed by geneticists was that mutations are almost always recessive to their wild-type alleles. Several explanations of this striking pattern have been offered. The two most influential are Fisher's theory--which argues that dominance results from natural selection against recurring deleterious mutations--and Wright's theory--which argues that dominance results from the physiology of gene action. The debate over which of these theories is correct represents one of the most protracted controversies in the history of evolutionary biology. Here I test Fisher's theory by assessing the dominance of mutations in an organism that is typically haploid, the alga Chlamydomonas reinhardtii. The results show that mutations are recessive just as often among haploid as among diploid species. This result falsifies Fisher's theory of dominance and provides strong support for the alternative physiological theory. |
| | |
Authors:
|
H A Orr |
Related Documents
:
|
17725975 - Evolution of a single niche specialist in variable environments. 20591865 - Parallel adaptive evolution of atlantic cod on both sides of the atlantic ocean in resp... 18573095 - Morphological plasticity in scleractinian corals. 17494755 - The theory of facilitated variation. 12801615 - Methylenetetrahydrofolate reductase (mthfr) 677c>t and methionine synthase reductase (m... 14534795 - Sequence polymorphism of the mitochondrial dna control region in the slovenian population. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 88 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1991 Dec |
Date Detail:
|
Created Date: 1992-02-07 Completed Date: 1992-02-07 Revised Date: 2010-09-07 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 11413-5 Citation Subset: IM; S |
Affiliation:
|
Center for Population Biology, University of California, Davis 95616. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alleles Animals Chlamydomonas reinhardtii / genetics* Chromosome Mapping Evolution* Genes, Dominant* Genes, Recessive Models, Genetic* Mutation* |
| Grant Support | |
ID/Acronym/Agency:
|
GM 38462/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Terminal region recognition factor 1, a DNA-binding protein recognizing the inverted terminal repeat...
Next Document: TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia...