Document Detail


A test of Fisher's theory of dominance.
MedLine Citation:
PMID:  1763055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the first patterns noticed by geneticists was that mutations are almost always recessive to their wild-type alleles. Several explanations of this striking pattern have been offered. The two most influential are Fisher's theory--which argues that dominance results from natural selection against recurring deleterious mutations--and Wright's theory--which argues that dominance results from the physiology of gene action. The debate over which of these theories is correct represents one of the most protracted controversies in the history of evolutionary biology. Here I test Fisher's theory by assessing the dominance of mutations in an organism that is typically haploid, the alga Chlamydomonas reinhardtii. The results show that mutations are recessive just as often among haploid as among diploid species. This result falsifies Fisher's theory of dominance and provides strong support for the alternative physiological theory.
Authors:
H A Orr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  88     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-07     Completed Date:  1992-02-07     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11413-5     Citation Subset:  IM; S    
Affiliation:
Center for Population Biology, University of California, Davis 95616.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Chlamydomonas reinhardtii / genetics*
Chromosome Mapping
Evolution*
Genes, Dominant*
Genes, Recessive
Models, Genetic*
Mutation*
Grant Support
ID/Acronym/Agency:
GM 38462/GM/NIGMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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