Document Detail


The teratology testing of food additives.
MedLine Citation:
PMID:  23138896     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The developmental and reproductive toxicity testing (including teratogenicity) of new foods and food additives is performed worldwide according to the guidelines given in the FDA Redbook. These studies are not required for substances that are generally recognized as safe, according to the FDA inventory. The anticipated cumulated human exposure level above which developmental or reproduction studies are required depends on the structure-alert category. For food additives of concern, both developmental (prenatal) and reproduction (multigeneration) studies are required. The developmental studies are performed in two species, usually the rat and the rabbit. The reproduction study is generally performed in the rat. The two rat studies are preferably combined into a single experimental design, if possible. The test methods described in the FDA Redbook are similar to those specified by the OECD for the reproductive toxicity testing of chemicals.
Authors:
Paul C Barrow; François Spézia
Related Documents :
22674216 - Environmental analysis of the logistics of agricultural products from roof top greenhou...
22547496 - Using the theory of planned behavior to predict two types of snack food consumption amo...
22317036 - Sustainability and cities: a proposal for implementation of a sustainable town.
22315676 - Food store environment modifies intervention effect on fruit and vegetable intake among...
21997496 - Regulations applicable to plant food supplements and related products in the european u...
24709486 - Consumer beliefs regarding farmed versus wild fish.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  947     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Affiliation:
CiToxLAB, Evreux, France, paul.barrow@citox.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Teratology Testing Under REACH.
Next Document:  Developmental toxicity testing of vaccines.