Document Detail

A teratologic study with the dyes amaranth and Ponceau 4R in mice.
MedLine Citation:
PMID:  1129808     Owner:  NLM     Status:  MEDLINE    
A teratology study on amaranth and Ponceau 4R was carried out in NMRI mice. The substances were given by gavage either from day 0 through day 7 or from day 6 through day 18 in doses of 7.5, 30 or 100 mg/kg. Distilled water was given by gavage to the control dams from day 0 through day 18. The foetuses were removed on day 18 for detailed examinations. No effect of treatment with the dyes could be observed with regard to number of implantations, frequency of foetal death and resorptions, gross malformations, skeletal or internal malformations or retarded growth as judged by foetal weight. The results are discussed with particular reference to the evaluation of teratologic studies on food colouring in general and the various regulation proposals from the National Food Administration.
K S Larsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  4     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1975  
Date Detail:
Created Date:  1975-08-04     Completed Date:  1975-08-04     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / etiology*,  pathology
Amaranth Dye / pharmacology*
Azo Compounds / pharmacology*
Bone and Bones / abnormalities
Coloring Agents / pharmacology*
Fetal Death / chemically induced
Fetus / physiology
Food Additives / pharmacology*
Mice, Inbred Strains
Naphthalenesulfonates / pharmacology*
Reproduction / drug effects
Teratogens / pharmacology*
Reg. No./Substance:
0/Azo Compounds; 0/Coloring Agents; 0/Food Additives; 0/Naphthalenesulfonates; 0/Teratogens; 915-67-3/Amaranth Dye

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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