Document Detail

The teratogenicity of drugs for nausea and vomiting of pregnancy: perceived versus true risk.
MedLine Citation:
PMID:  12011895     Owner:  NLM     Status:  MEDLINE    
Women and health care providers commonly overestimate the teratogenic risk of medications in pregnancy. With regard to nausea and vomiting of pregnancy, this leads to an underutilization of pharmacologic therapy. Pregnancy termination has even been elected in some circumstances when safe and effective alternatives for nausea have not been attempted. The misperception of teratogenic risk is partly the result of the way data on safety are presented. An awareness of this can lead to more balanced patient and physician educational materials. To facilitate rational use of medicinal and nonmedicinal therapy for nausea and vomiting of pregnancy, we have developed an algorithm based on a recent systematic review of safety and efficacy in management of the problem. The hierarchical use of medication is based on strength of evidence of fetal safety.
Gideon Koren; Zina Levichek
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  186     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-06-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S248-52     Citation Subset:  AIM; IM    
Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Abnormalities, Drug-Induced*
Abortion, Induced
Antiemetics / adverse effects*
Nausea / drug therapy*
Pregnancy Complications / drug therapy*
Vomiting / drug therapy*
Reg. No./Substance:

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