Document Detail

A ten-year remission maintained by 6,272 mg (3,920 mg/m2) cumulative dose of cisplatin-based chemotherapy for recurrent epithelial ovarian cancer.
MedLine Citation:
PMID:  11874068     Owner:  NLM     Status:  MEDLINE    
Since cisplatin is a heavy metal, renal and neurotoxicity is considered to be dose limiting in solid tumors. The current case is unusual in that remission has been maintained in a patient with recurrent epithelial ovarian cancer by cisplatin-based chemotherapy without evidence of renal or neurotoxicity, while receiving a total dose of 6,270 mg (3,920 mg/m2) of cisplatin over 11 1/2 years.
M S Piver
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  22     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-04     Completed Date:  2002-08-15     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  403-5     Citation Subset:  IM    
Sisters of Charity Hospital, Buffalo, NY 14214, USA.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Cisplatin / administration & dosage*,  adverse effects
Kidney / drug effects
Neoplasm Recurrence, Local / drug therapy*
Neoplasms, Glandular and Epithelial / drug therapy*
Ovarian Neoplasms / drug therapy*
Reg. No./Substance:

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