Document Detail


A ten percent prevalence of asymptomatic familial intracranial aneurysms: preliminary report on 110 magnetic resonance angiography studies in members of 21 Finnish familial intracranial aneurysm families.
MedLine Citation:
PMID:  7969827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The population in eastern Finland has been stable for generations, causing a high degree of genetic isolation and providing excellent possibilities for follow-up studies. Of 91 families with familial intracranial aneurysms, 21 were randomly selected for prospective magnetic resonance angiography studies for intracranial aneurysms. Sixteen intracranial aneurysms were detected in 11 asymptomatic family members of a total of 110 studied. The prevalence of intracranial aneurysms among these familial intracranial aneurysm families is 10%, approximately 10 times higher than in the average population. Our findings suggest that family members of familial intracranial aneurysm families should be examined for intracranial aneurysms. Familial intracranial aneurysm may be a genetic disorder.
Authors:
A Ronkainen; J Hernesniemi; M Ryynänen; M Puranen; H Kuivaniemi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurosurgery     Volume:  35     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  208-12; discussion 212-3     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Angiography, Digital Subtraction
Cerebral Angiography
Female
Finland
Gene Frequency
Genetic Testing
Humans
Intracranial Aneurysm / diagnosis,  genetics*
Magnetic Resonance Angiography*
Male
Middle Aged
Phenotype
Polycystic Kidney Diseases / diagnosis,  genetics
Prospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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