| The temporal variability of dominant frequency and complex fractionated atrial electrograms constrains the validity of sequential mapping in human atrial fibrillation. | |
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MedLine Citation:
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PMID: 20156614 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: It has been proposed that sequential mapping of dominant frequency (DF) and complex fractionated atrial electrograms (CFAE) can identify target sites for ablation of atrial fibrillation (AF). These mapping strategies are valid only if DF and CFAE are temporally stable on the timescale of the mapping procedure. We postulate that DF and CFAE are temporally variable; consequently, sequential mapping can be misleading. OBJECTIVE: To make prolonged spatially stable multielectrode recordings to assess the temporal stability of DF and CFAE. METHODS: We recorded electrical activity for 5 minutes with the use of a 64-electrode basket catheter placed in the left atrium of 18 patients presenting for AF ablation. DF and CFAE were determined off-line, and their temporal variability was quantified. Maps created from simultaneous versus sequentially acquired data were compared. RESULTS: DF was temporally variable: the average temporal coefficient of variation was 22.7% +/- 5.4%. DF sites were transient, meeting criteria for only 22.1 seconds out of 5 minutes. Similarly, CFAEs were transient (average duration of CFAE 8.8 +/- 11.3 seconds). DF and CFAE sequential maps failed to identify 93.0% +/- 12.4% and 35.9% +/- 14.9% of DF and CFAE sites, respectively. CONCLUSION: Because of temporal variability, sequential DF and CFAE maps do not accurately reflect the spatial distribution of excitation frequency during any given sampling interval. The spatial distribution of DF and CFAE sites on maps created with sequential point acquisition depends upon the time at which each site is sampled. |
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Authors:
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Nicole Habel; Pierre Znojkiewicz; Nathaniel Thompson; Joachim G Müller; Bryan Mason; James Calame; Susan Calame; Shruti Sharma; Gagan Mirchandani; Deborah Janks; Jason Bates; Arshia Noori; Andreas Karnbach; Daniel L Lustgarten; Burton E Sobel; Peter Spector |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-01-11 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 7 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
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Languages: eng Pagination: 586-93 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine at the University of Vermont College of Medicine, Burlington, Vermont 05401, USA. |
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Comment In:
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Heart Rhythm. 2010 May;7(5):594-5
[PMID:
20156613
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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