Document Detail


The temporal and spatial expression pattern of myosin Va, Vb and VI in the mouse ovary.
MedLine Citation:
PMID:  16713372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are 16 classes of unconventional myosins. Class V myosins have been shown to be involved in transporting cargo to and from the cell periphery. Class VI myosins have also been shown to transport cargo from the cell periphery, although it seems that these proteins have many roles which include the mediation of cell migration and stereocillia stabilisation. With the requirement of myosin VI for Drosophila oogenesis, the localised expression of Myosin V in the developing egg chamber and recent mounting evidence which links myosin VI to the migration of human ovarian cancer cell lines, we wanted to investigate the expression pattern of these two myosin classes in the normal mouse ovary. Here we show that these myosins are expressed, localised and regulated within the oocyte and granulosa cells of the developing mouse follicle.
Authors:
Leeanne McGurk; George Tzolovsky; Norah Spears; Mary Bownes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-06
Journal Detail:
Title:  Gene expression patterns : GEP     Volume:  6     ISSN:  1567-133X     ISO Abbreviation:  Gene Expr. Patterns     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-11     Completed Date:  2006-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167473     Medline TA:  Gene Expr Patterns     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  900-7     Citation Subset:  IM    
Affiliation:
MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, United Kingdom. leeanne.mcgurk@hgu.mrc.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Gene Expression Regulation, Developmental
Granulosa Cells / metabolism
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Myosin Heavy Chains / metabolism*
Myosin Type V / metabolism*
Ovarian Follicle / growth & development,  metabolism
Ovary / cytology,  growth & development*,  metabolism*
RNA, Messenger / metabolism
Chemical
Reg. No./Substance:
0/MYO5B protein, human; 0/Myo5a protein, mouse; 0/Myosin Heavy Chains; 0/RNA, Messenger; 0/myosin VI; EC 3.6.1.-/Myosin Type V

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