| The temperature dependence of cardioplegic distribution in the canine heart. | |
| | |
MedLine Citation:
|
PMID: 10969689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cold cardioplegic arrest can produce cooling contracture and suboptimal myocardial protection. This study examines whether cooling contracture is associated with maldistribution of cardioplegic solution, particularly subendocardial hypoperfusion, which may impair recovery. METHODS: Canine hearts were arrested by antegrade cold and warm blood cardioplegia in random order. Cardioplegic distribution was measured using radiolabeled microspheres before and just after induction of each period of arrest. RESULTS: With cold cardioplegia, perfusion of left ventricular subepicardial and midwall regions decreased. Subendocardial to subepicardial perfusion ratios increased significantly in the left ventricle as a whole, the anterior and posterior regions of the left ventricular free wall, and the interventricular septum. With warm arrest, transmural flow distribution was not significantly altered from preceding prearrest values. At constant coronary flow, coronary perfusion pressure was initially similar after induction of arrest at both temperatures, but it rose subsequently during warm cardioplegia. CONCLUSIONS: The data suggest that during normothermic arrest, vasomotor tone regulates cardioplegic distribution, and hyperkalemic vasoconstriction is of slow onset. In the absence of beating and with vasomotion inhibited by hypothermia, cardioplegic distribution during cold arrest appears to be primarily dependent on vascular anatomy. There was no evidence of subendocardial underperfusion during cooling contracture. |
| | |
Authors:
|
D F Torchiana; A J Vine; J S Titus; C Hahn; K O Shebani; G A Geffin; W M Daggett |
Related Documents
:
|
6466019 - Cold hemagglutination pathophysiology. evaluation and management of patients undergoing... 3172809 - Effects of antegrade cardioplegic infusion with simultaneously controlled coronary sinu... 6411999 - Time course of ischemic alterations during normothermic and hypothermic arrest and its ... 6179199 - Prolonged safe ischemic cardiac arrest using hypothermic bretschneider cardioplegia com... 2132419 - Long-term preservation of donor hearts: the effect of intra- and extracellular-type of ... 10355409 - Effects of cardioplegic flushing, storage, and reperfusion on coronary circulation in t... 1576039 - Thrombolytics. 8551189 - Electric instability after myocardial infarction displayed in body surface potential maps. 19083309 - Right ventricular aneurysm and atrial septal defect in a cat. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 70 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2000 Aug |
Date Detail:
|
Created Date: 2000-09-27 Completed Date: 2000-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 614-20 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA. torchiana.david@mgh.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardioplegic Solutions / pharmacokinetics* Coronary Vessels / physiology Dogs Evaluation Studies as Topic Female Heart / physiology* Heart Arrest, Induced* Male Microspheres Random Allocation Regional Blood Flow Temperature* Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
|
HL12322/HL/NHLBI NIH HHS; HL12777/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cardioplegic Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Amrinone preconditioning in the isolated perfused rabbit heart.
Next Document: Age dependence of heat stress mediated cardioprotection.