| The telomere-telomerase axis and the heart. | |
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MedLine Citation:
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PMID: 17034355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preservation of myocyte number and cardiac mass throughout life is dependent on the balance between cell death and cell division. Rapidly emerging evidence indicates that new myocytes can be formed through the activation and differentiation of resident cardiac progenitor cells. The critical issue is the identification of mechanisms that define the aging of cardiac progenitor cells and, ultimately, their inability to replace dying myocytes. The most reliable marker of cellular senescence is the modification of the telomere-telomerase axis, together with the expression of the cell cycle inhibitors p16INK4a and p53. Cellular senescence is characterized by biochemical events that occur within the cell. In this regard, one of the most relevant processes is represented by repeated oxidative stress that may evolve into the activation of the cell death program or result in the development of a senescent phenotype. Thus, the modulation of telomerase activity and the control of telomeric length, together with the attenuation of the formation of reactive oxygen species, may represent important therapeutic tools in regenerative medicine and in prevention of aging and diabetic cardiomyopathies. |
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Authors:
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Jan Kajstura; Marcello Rota; Konrad Urbanek; Toru Hosoda; Claudia Bearzi; Piero Anversa; Roberto Bolli; Annarosa Leri |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 8 ISSN: 1523-0864 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-10-12 Completed Date: 2007-01-30 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 2125-41 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA. jan_kajstura@nymc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / etiology, metabolism*, prevention & control Cell Aging / physiology* Homeostasis / physiology Humans Myocardium / enzymology, metabolism* Oxidative Stress / physiology* Reactive Oxygen Species / metabolism Telomerase / metabolism* Telomere / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AG-17042/AG/NIA NIH HHS; AG-23071/AG/NIA NIH HHS; AG-26107/AG/NIA NIH HHS; HL-38132/HL/NHLBI NIH HHS; HL-55757/HL/NHLBI NIH HHS; HL-65577/HL/NHLBI NIH HHS; HL-70897/HL/NHLBI NIH HHS; HL-75480/HL/NHLBI NIH HHS; HL-78825/HL/NHLBI NIH HHS; HL-81737/HL/NHLBI NIH HHS; HL65573/HL/NHLBI NIH HHS; HL68088/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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