| The telomerase inhibitor telomestatin induces telomere shortening and cell death in Arabidopsis. | |
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MedLine Citation:
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PMID: 16473138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cellular response to telomere dysfunction in plants was investigated with the use of telomestatin, an inhibitor of human telomerase activity. Telomestatin bound to plant telomeric repeat sequence, and inhibited telomerase activity in suspension-cultured cells of Arabidopsis thaliana and Oryza sativa (rice) in a dose-dependent manner. The inhibitor did not affect transcript level of the TERT gene, which encodes the catalytic subunit of telomerase, in the plant cells. Inhibition of telomerase activity by telomestatin resulted in rapid shortening of telomeres and the induction of cell death by an apoptosis-like mechanism in Arabidopsis cells. These results suggest that telomerase contributes to the survival of proliferating plant cells by maintaining telomere length, and that telomere erosion triggers cell death. |
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Authors:
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Lili Zhang; Katsunori Tamura; Kazuo Shin-ya; Hideo Takahashi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-29 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1763 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-02-13 Completed Date: 2006-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 39-44 Citation Subset: IM |
Affiliation:
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Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
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cytology*,
drug effects,
enzymology*,
genetics Cell Death / drug effects Cells, Cultured Oryza sativa / enzymology Oxazoles / pharmacology* RNA, Messenger / genetics, metabolism Telomerase / antagonists & inhibitors*, metabolism Telomere / chemistry, genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Oxazoles; 0/RNA, Messenger; 0/telomestatin; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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