Document Detail

The telomerase inhibitor telomestatin induces telomere shortening and cell death in Arabidopsis.
MedLine Citation:
PMID:  16473138     Owner:  NLM     Status:  MEDLINE    
The cellular response to telomere dysfunction in plants was investigated with the use of telomestatin, an inhibitor of human telomerase activity. Telomestatin bound to plant telomeric repeat sequence, and inhibited telomerase activity in suspension-cultured cells of Arabidopsis thaliana and Oryza sativa (rice) in a dose-dependent manner. The inhibitor did not affect transcript level of the TERT gene, which encodes the catalytic subunit of telomerase, in the plant cells. Inhibition of telomerase activity by telomestatin resulted in rapid shortening of telomeres and the induction of cell death by an apoptosis-like mechanism in Arabidopsis cells. These results suggest that telomerase contributes to the survival of proliferating plant cells by maintaining telomere length, and that telomere erosion triggers cell death.
Lili Zhang; Katsunori Tamura; Kazuo Shin-ya; Hideo Takahashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-29
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1763     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-13     Completed Date:  2006-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan.
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MeSH Terms
Arabidopsis / cytology*,  drug effects,  enzymology*,  genetics
Cell Death / drug effects
Cells, Cultured
Oryza sativa / enzymology
Oxazoles / pharmacology*
RNA, Messenger / genetics,  metabolism
Telomerase / antagonists & inhibitors*,  metabolism
Telomere / chemistry,  genetics,  metabolism*
Reg. No./Substance:
0/Oxazoles; 0/RNA, Messenger; 0/telomestatin; EC

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