Document Detail


The telomerase cycle: normal and pathological aspects.
MedLine Citation:
PMID:  15630594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomeres are nucleoprotein complexes that cap the end of eukaryotic chromosomes and are essential for their function and stability. Telomerase, a reverse transcriptase that extends the single-stranded G-rich 3' protruding ends of chromosomes, stabilizes telomere length in germ line cells and regenerative tissues as well as in tumor cells. In the absence of telomerase telomeres shorten with cell division, a process able to trigger cell growth arrest. When telomerase is present in the cell, its activity is tightly regulated at its site of action by factors specifically bound to the telomeric DNA. Recent data indicate that telomeres reorganize during the cell cycle. This review summarizes our current knowledge on how telomeres are dynamically organized and remodeled during cell cycle and stress response, pointing out the conservation and the difference between yeast and human. We then focus on the cellular consequences of telomere modifications in normal and cancer cells. This leads to a discussion of the different roles, seemingly contradictory, of telomeres and telomerase during the initiation and the progression of a cancer.
Authors:
Michele Brunori; Pierre Luciano; Eric Gilson; Vincent Géli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-01-04
Journal Detail:
Title:  Journal of molecular medicine (Berlin, Germany)     Volume:  83     ISSN:  0946-2716     ISO Abbreviation:  J. Mol. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-20     Completed Date:  2005-07-26     Revised Date:  2011-07-08    
Medline Journal Info:
Nlm Unique ID:  9504370     Medline TA:  J Mol Med (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  244-57     Citation Subset:  IM    
Affiliation:
Laboratoire de Biologie Moleculaire de la Cellule, l'Ecole Normale de Lyon, CNRS UMR5161, INRA U1237, IFR12846 Allée d'Italie, 69364 Lyon cedex 07, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / genetics
Genes, Tumor Suppressor
Humans
Oncogenes
Reference Values
Telomerase / physiology*
Telomere / physiology
Yeasts / enzymology,  genetics
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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