Document Detail

A technique for producing demyelination of the rat optic nerves.
MedLine Citation:
PMID:  15639414     Owner:  NLM     Status:  MEDLINE    
Demyelination is a major cause of neurological disability within the human population, and the end product of a number of pathological processes, though the most common is the disease multiple sclerosis. This disease commonly affects the optic pathway, particularly the optic nerve and chiasm. This paper reports a novel technique of producing chemical glial toxin induced demyelination in the rat optic nerves and chiasm by the direct instillation of the glial toxin ethidium bromide into the rat cranial subarachnoid space causing demyelination of the optic nerves and chiasm. This model, because of its involvement of the optic pathways, will allow both histological and functional assessments of the processes of demyelination and remyelination in the rat animal model.
Eric P Guazzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  12     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-10     Completed Date:  2006-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  54-8     Citation Subset:  IM    
Department of Surgery, School of Medicine, James Cook University, Townsville, Qld, Australia.
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MeSH Terms
Coloring Agents
Demyelinating Diseases / chemically induced*,  pathology*
Fluorescent Dyes
Myelin Sheath / pathology
Optic Chiasm / pathology
Optic Nerve / pathology*
Optic Nerve Diseases / chemically induced*,  pathology*
Rats, Sprague-Dawley
Reflex, Pupillary / physiology
Tissue Fixation
Visual Pathways / pathology
Reg. No./Substance:
0/Coloring Agents; 0/Fluorescent Dyes; 3546-21-2/Ethidium

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