Document Detail

A technique for intracisternal collection and administration in a rhesus macaque.
MedLine Citation:
PMID:  20859278     Owner:  NLM     Status:  MEDLINE    
Accessing the subarachnoid space via intrathecal needle placement can be done in nonhuman primates (NHPs) and other species to collect cerebral spinal fluid (CSF) or to deliver agents into the CSF. Researchers can use a variety of techniques for intrathecal collection and administration. Drawing on various published resources and previous experience with intracisternal CSF sampling, the authors sought to modify one collection technique to include CSF administration. Here, the authors describe how they collected CSF from the cisterna magna of rhesus macaques (Macaca mulatta) and administered substances through the cisterna magna into the CSF. They identify potential concerns that they had when developing the technique and describe how they alleviated those concerns. The authors found this technique, which relies heavily on teamwork, to be an effective method for intracisternal injection of an experimental compound.
Karen J Clingerman; Susan Spray; Claudia Flynn; Howard S Fox
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Lab animal     Volume:  39     ISSN:  0093-7355     ISO Abbreviation:  Lab Anim (NY)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417737     Medline TA:  Lab Anim (NY)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
The Scripps Research Institute, La Jolla, CA, USA.
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MeSH Terms
Cerebral Ventricles
Cerebrospinal Fluid
Injections, Spinal / methods,  veterinary*
Macaca mulatta*
Paracentesis / methods,  veterinary*
Grant Support

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