| The targeted podocyte. | |
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MedLine Citation:
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PMID: 21606599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental settings. In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the mTOR system shed light on the complexity of this pathway in the podocyte. |
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Authors:
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Agnes B Fogo |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural Date: 2011-05-23 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 121 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-02 Completed Date: 2011-08-17 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 2142-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. agnes.fogo@vanderbilt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Carrier Proteins / genetics, physiology Child Diabetic Nephropathies / genetics, metabolism, pathology, prevention & control Disease Models, Animal Genetic Predisposition to Disease Humans Kidney Glomerulus / pathology, physiopathology Mice Mice, Inbred C57BL Podocytes / drug effects, pathology, physiology* Proteins / antagonists & inhibitors, physiology Sirolimus / therapeutic use TOR Serine-Threonine Kinases / antagonists & inhibitors, physiology Trans-Activators / antagonists & inhibitors, physiology Transcription Factors / physiology |
| Grant Support | |
ID/Acronym/Agency:
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P50 DK44757/DK/NIDDK NIH HHS; R01DK56942/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CRTC2 protein, human; 0/Carrier Proteins; 0/Proteins; 0/TORC2 protein, mouse; 0/Trans-Activators; 0/Transcription Factors; 0/mTORC1 complex, human; 0/mTORC1 complex, mouse; 0/raptor protein, mouse; 0/rictor protein, mouse; 53123-88-9/Sirolimus; EC 2.7.1.1/TOR Serine-Threonine Kinases |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2011 Jun;121(6):2197-209
[PMID:
21606591
]
J Clin Invest. 2011 Jun;121(6):2181-96 [PMID: 21606597 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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