| A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. | |
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MedLine Citation:
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PMID: 20962850 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Multiple genetic and environmental factors contribute to the pathogenesis of this disease. Recent genome-wide association studies have added substantially to the number of genes associated with SLE. To replicate some of these susceptibility loci, single-nucleotide polymorphisms reported to be associated to SLE were evaluated in a cohort of 245 well-phenotyped Canadian SLE trios. Our results replicate previously reported associations to alleles of interferon regulatory factor 5 (IRF5), major histocompatibility complex (MHC), tumor necrosis factor (ligand) superfamily member 4 (TNFSF4), Kell blood group complex subunit-related family member 6 (XKR6), B-cell scaffold protein with ankyrin repeats 1 (BANK1), protein tyrosine phosphatase non-receptor type 22 (PTPN22), ubiquitin-conjugating enzyme E2L 3 (UBE2L3) and islet cell autoantigen 1 (ICA1). We also identify putative associations to cytotoxic T-lymphocyte-associated protein 4 (CTLA4), a gene associated with several autoimmune disorders, and ERBB3, a locus on 12q13 that was previously reported to be associated with type 1 diabetes. This study confirms the existence of multiple genetic risk factors for SLE, and supports the notion that some risk factors for SLE are shared with other inflammatory disorders. |
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Authors:
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M L Budarf; P Goyette; G Boucher; J Lian; R R Graham; J O Claudio; T Hudson; D Gladman; A E Clarke; J E Pope; C Peschken; C D Smith; J Hanly; E Rich; G Boire; S G Barr; M Zummer; ; P R Fortin; J Wither; J D Rioux |
Publication Detail:
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Type: Journal Article Date: 2010-10-21 |
Journal Detail:
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Title: Genes and immunity Volume: 12 ISSN: 1476-5470 ISO Abbreviation: Genes Immun. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100953417 Medline TA: Genes Immun Country: England |
Other Details:
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Languages: eng Pagination: 51-8 Citation Subset: IM |
Affiliation:
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Research Center, Montreal Heart Institute, Montreal, Quebec, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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