| A target based therapeutic approach towards diabetes mellitus using medicinal plants. | |
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MedLine Citation:
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PMID: 18991598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes mellitus (DM) is not one disease but is a heterogonous group of syndromes. Contrary to the popular belief DM is a metabolic disorder characterized by increased blood glucose level (hyperglycemia) and this is because of insufficient or inefficient insulin secretary response. Glucose is the main energy source for the body, and in the case of DM, management of glucose becomes irregular. There are around 410 experimentally proven medicinal plants having antidiabetic properties but the complete mechanism of action is available only for about 109. There are several medicinal plants whose extract modulate glycolysis, Krebs cycle, gluconeogenesis, HMP shunt pathway, glycogen synthesis and their degradation, cholesterol synthesis, metabolism and absorption of carbohydrates, and synthesis and release of insulin. This paper provides a comprehensive review of the mode of action of medicinal plants that exhibit anti-diabetic properties. |
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Authors:
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Pranav K Prabhakar; Mukesh Doble |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current diabetes reviews Volume: 4 ISSN: 1875-6417 ISO Abbreviation: - Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2009-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101253260 Medline TA: Curr Diabetes Rev Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 291-308 Citation Subset: IM |
Affiliation:
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Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / drug effects, metabolism Citric Acid Cycle / drug effects Diabetes Mellitus / drug therapy* Disease Models, Animal Gluconeogenesis / drug effects Glucose / metabolism Glycolysis / drug effects Herbal Medicine Humans Hypoglycemic Agents / isolation & purification, therapeutic use* Plant Extracts / therapeutic use* Plants, Medicinal* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Plant Extracts; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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