| A CDE/CHR tandem element regulates cell cycle-dependent repression of cyclin B2 transcription. | |
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MedLine Citation:
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PMID: 11068036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclin B is an important regulator of progression through the cell division cycle. The oscillating appearance of cyclin B1 and B2 proteins during the cell cycle is in part due to fluctuating mRNA levels. We had identified earlier a tandem promoter element named cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) which regulates cell cycle-dependent transcription of cdc25C, cyclin A and cdc2. Here we describe that cyclin B2 transcription is repressed through a novel CDE/CHR element in resting and G(1) cells. By relief of this repression in S and G(2) oscillating expression of cyclin B2 mRNA is achieved during the cell cycle. |
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Authors:
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C Lange-zu Dohna; M Brandeis; F Berr; J Mössner; K Engeland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 484 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-17 Completed Date: 2000-12-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 77-81 Citation Subset: IM |
Affiliation:
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Medizinische Klinik II, Department of Internal Medicine, University of Leipzig, Leipzig, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cell Cycle / genetics Cells, Cultured Cyclin B / genetics*, metabolism Cyclin B2 DNA / analysis Gene Silencing Mice Molecular Sequence Data Promoter Regions, Genetic / genetics* Sequence Homology, Nucleic Acid Simian virus 40 / genetics Tandem Repeat Sequences / genetics* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Ccnb2 protein, mouse; 0/Cyclin B; 0/Cyclin B2; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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