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The tall cell variant of papillary thyroid carcinoma: clinical and pathological features and outcomes.
MedLine Citation:
PMID:  22776915     Owner:  NLM     Status:  Publisher    
Background: The tall cell variant (TCV) is a relatively rare variant of papillary thyroid cancer. Since a controversy exists whether or not the TCV has a worse outcome, the aim of our study was to retrospectively compare the clinicopathological features and outcomes in a group of TCV patients and a larger group of patients with classical papillary thyroid carcinoma (cPTC). Subjects and Methods: Data from 30 TCV patients and 293 cPTC were analysed. Among the 293 cPTC, we also selected a "high-risk" cPTC group (n=103) that was treated with the same protocol used for the TCV patients. All data were managed by Cox analysis. Results: Compared to all cPTCs, TCVs displayed only a significantly higher rate of extrathyroid extension. At multivariate analysis, TCV was not an independent variable for the prediction of a high risk of persistent/recurrent disease. At the last follow-up observation, there was no difference in the disease status between the TCV and all cPTC patients. Moreover, "high-risk" cPTC patients had a significant increase in persistent/recurrent disease. Conclusions: In our study, despite the TCV histotype is associated with a higher prevalence of extrathyroid extension, it is characterized by an outcome that is not significantly different than that of all cPTC patients and is more favorable than that of "high-risk" cPTC patients. Only those TCV patients classified as "high risk" based on specific pathological and clinical features, according to current guidelines, should be treated aggressively, such as with a total thyroidectomy, neck lymph node dissection or ablative radioiodine treatment.
Concetto Regalbuto; Pasqualino Malandrino; Francesco Frasca; Gabriella Pellegriti; Rosario Le Moli; Riccardo Vigneri; Vincenzo Pezzino
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-9
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Endocrinology, Department of Clinical and Molecular Bio-Medicine of the University of Catania, Garibaldi-Nesima Hospital, Catania, Italy.
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