Document Detail


A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys.
MedLine Citation:
PMID:  3713205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rhesus monkeys were restrained in chairs from which their tails hung free so that their tails could be immersed into a thermos of water. Monkeys consistently kept their tails in 38-40 degrees C water for at least 20 sec, but withdrew them from 55 degrees C water in 1-4 sec. Tail withdrawal latencies from 55 degrees C water remained consistent over a period of 3 hr. Morphine produced dose-dependent increases in tail withdrawal latencies from 55 degrees C water, whereas pentobarbital, haloperidol, and phencyclidine did not increase tail withdrawal latencies except at doses that produced marked sedation.
Authors:
L A Dykstra; J H Woods
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmacological methods     Volume:  15     ISSN:  0160-5402     ISO Abbreviation:  J Pharmacol Methods     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-14     Completed Date:  1986-07-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806596     Medline TA:  J Pharmacol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Dose-Response Relationship, Drug
Female
Haloperidol / pharmacology
Hot Temperature / adverse effects
Male
Morphine / pharmacology
Pain / drug therapy*,  etiology
Pentobarbital / pharmacology
Phencyclidine / pharmacology
Reaction Time / drug effects
Grant Support
ID/Acronym/Agency:
DA 00033/DA/NIDA NIH HHS; DA 00254/DA/NIDA NIH HHS; DA 02749/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics; 52-86-8/Haloperidol; 57-27-2/Morphine; 76-74-4/Pentobarbital; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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