| tRNA and cytochrome c in cell death and beyond. | |
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MedLine Citation:
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PMID: 20676046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both transfer RNA (tRNA) and cytochrome c are essential to cellular function: tRNA mediates protein synthesis while cytochrome c is required for oxidative phosphorylation and apoptosis induction. tRNA has recently been implicated as a direct regulator of the well-conserved apoptotic role of cytochrome c. Interaction between these molecules could potentially coordinate biosynthesis, energy production and apoptosis. Here we review the diversity and dynamics of tRNA and how this class of non-coding RNAs may regulate the role of cytochrome c in apoptosis. We comment on unanswered questions in the cell biology of this interaction and how answers may influence our understanding of disease. |
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Authors:
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Yide Mei; Jeongsik Yong; Aaron Stonestrom; Xiaolu Yang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-08-07 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-12-01 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2936-9 Citation Subset: IM |
Affiliation:
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Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Death Cytochromes c / metabolism* Disease / genetics Humans Protein Binding RNA, Transfer / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA108872/CA/NCI NIH HHS; GM60911/GM/NIGMS NIH HHS; R01 CA088868-09/CA/NCI NIH HHS; R01 GM060911-06A2/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-43-6/Cytochromes c; 9014-25-9/RNA, Transfer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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