| t10,c12-18:2-induced milk fat depression is less pronounced in cows fed high-concentrate diets. | |
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MedLine Citation:
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PMID: 20803173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In intensively reared dairy cows, milk fat secretion is reduced in response to high-concentrate diets and it is often referred to as the "milk fat depression" (MFD) syndrome. Some trans fatty acid (FA) isomers produced in the rumen of the cows, including t10,c12-18:2, are known for their inhibitory effect on mammary lipogenesis. To study whether this effect depends on the basal diet, duodenal infusions of t10,c12-18:2 were performed on cows fed four different diets (a factorial arrangement of forage:concentrate ratio and linseed oil supplementation). The overall response obtained with t10,c12-18:2 infusion was consistent with previous studies: a decrease in milk fat content and yield without significant variations in milk yield. Mean transfer efficiency of infused t10,c12-18:2 was 19.6%. However, the decrease in milk fat and FA yields (both de novo synthesis and preformed long-chain FA) was less pronounced in cows fed high-concentrate diets (-27% of the initial level), compared with cows fed low-concentrate diets (-42% of initial level). This difference was independent of dietary oil supplementation and milk FA yield before infusion. Results pertaining to effects of dietary forage:concentrate ratio were confirmed by statistical meta-analysis of data from previously published t10,c12-18:2 infusion experiments. This study shows that in cows fed MFD diets the mammary gland becomes more resistant to or experiences a lower response potential to further inhibition of lipogenesis and/or delta-9 desaturation of FA. |
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Authors:
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Frédéric Glasser; Anne Ferlay; Michel Doreau; Juan J Loor; Yves Chilliard |
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Publication Detail:
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Type: Journal Article Date: 2010-08-28 |
Journal Detail:
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Title: Lipids Volume: 45 ISSN: 1558-9307 ISO Abbreviation: Lipids Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: Germany |
Other Details:
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Languages: eng Pagination: 877-87 Citation Subset: IM |
Affiliation:
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INRA, UR1213 Herbivores, Site de Theix, 63122, Saint-Genès-Champanelle, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed* Animals Cattle Fatty Acids / analysis* Linoleic Acids, Conjugated / administration & dosage, pharmacology* Linseed Oil / administration & dosage Milk / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Linoleic Acids, Conjugated; 0/trans-10,cis-12-conjugated linoleic acid; 8001-26-1/Linseed Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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