Document Detail

The systemic right ventricle in congenitally corrected transposition of the great arteries is different from the right ventricle in dextro-transposition after atrial switch: a cardiac magnetic resonance study.
MedLine Citation:
PMID:  22694856     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with a congenitally corrected transposition of the great arteries show an increasing incidence of cardiac failure with age. In other systemic right ventricles, such as in dextro-transposition after atrial switch, excessive hypertrophy is a potential risk factor for impaired systolic function. In this trial, we sought to compare systemic function and volumes between patients with congenitally corrected transposition and those with dextro-transposition after atrial switch by using cardiac magnetic resonance imaging.
METHODS AND RESULTS: A total of 19 patients (nine male) with congenitally corrected transposition and 31 patients (21 male) with dextro-transposition after atrial switch were studied using a 1.5-Tesla scanner. Cine steady-state free-precession sequences in standard orientations were acquired for volumetric and functional imaging. Patient parameters were compared with those of a group of 25 healthy volunteers. Although patients with congenitally corrected transposition were older, they presented with higher right ventricular ejection fractions (p = 0.04) compared with patients with dextro-transposition. Patients with congenitally corrected transposition showed a weak negative correlation between age at examination and systemic ejection fraction (r = −0.18, p = 0.04) but no correlation between right ventricular myocardial mass index and ejection fraction. There was no significant difference in the right ventricular end-diastolic volumes between both patient groups.
CONCLUSION: Although patients with congenitally corrected transposition had a longer pressure load of the systemic right ventricle, ventricular function was better compared with that in patients with dextro-transposition after atrial switch. The results suggest that the systemic ventricles might have partly different physiologies. One difference could be the post-operative situation after atrial switch, which results in impaired atrial contribution to ventricular filling.
Matthias Grothoff; Antje Fleischer; Hashim Abdul-Khaliq; Janine Hoffmann; Lukas Lehmkuhl; Christian Luecke; Matthias Gutberlet
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Publication Detail:
Type:  Journal Article     Date:  2012-06-14
Journal Detail:
Title:  Cardiology in the young     Volume:  23     ISSN:  1467-1107     ISO Abbreviation:  Cardiol Young     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-06-11     Completed Date:  2014-02-10     Revised Date:  2014-02-18    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  England    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Heart Atria / surgery
Heart Failure / etiology,  pathology,  physiopathology
Heart Ventricles / pathology,  physiopathology*
Hypertrophy, Right Ventricular / etiology,  pathology,  physiopathology*
Magnetic Resonance Imaging, Cine
Middle Aged
Transposition of Great Vessels / complications,  pathology,  physiopathology*,  surgery
Ventricular Dysfunction, Right / etiology,  pathology,  physiopathology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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