| The systemic inflammatory response to exercise in adults with cystic fibrosis. | |
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MedLine Citation:
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PMID: 16403491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise is associated with release of inflammatory mediators in the circulation and there is evidence that the exercising muscles and tendons are sources of interleukin-6. Due to the catabolic effects of some cytokines, increased release in circulation might contribute to alterations in body composition in adults with cystic fibrosis. We hypothesised that exercise of moderate intensity would generate increased blood concentrations of some inflammatory mediators. We investigated the change in blood concentrations of interleukin-6, tumour necrosis factor alpha and their soluble receptors after a structured exercise (box stepping) of intensity similar to that encountered during activities of daily living in 12 adults with cystic fibrosis and mean (95% confidence interval) FEV1 55.6 (44.4, 66.8)% predicted, body mass index 23.0 (21.3, 24.6) kg/m2 and 12 healthy subjects. The increments post-exercise for all inflammatory mediators and lactate corrected for the work performed until voluntary exhaustion were greater for patients, while the total work was less for patients (all p<0.01). Daytime variability of the inflammatory mediators was assessed in eight patients and was less than the change due to exercise. We report greater increments in circulating concentrations of some cytokines with moderate exercise in adults with cystic fibrosis compared to healthy subjects. |
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Authors:
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Alina A Ionescu; Timothy D Mickleborough; Charlotte E Bolton; Martin R Lindley; Lisette S Nixon; Gareth Dunseath; Steve Luzio; David R Owens; Dennis J Shale |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-03 |
Journal Detail:
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Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: 5 ISSN: 1569-1993 ISO Abbreviation: J. Cyst. Fibros. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-02 Completed Date: 2006-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: Netherlands |
Other Details:
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Languages: eng Pagination: 105-12 Citation Subset: IM |
Affiliation:
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Respiratory Medicine, Cardiff University, Academic Centre, Llandough Hospital, Cardiff, CF64 2XX, United Kingdom. ionescuaa@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaerobic Threshold Cystic Fibrosis / blood*, physiopathology Exercise / physiology* Female Forced Expiratory Volume Humans Inflammation / blood*, physiopathology Interleukin-6 / blood Lactic Acid / blood Male Oxygen Consumption Receptors, Interleukin-6 / blood Receptors, Tumor Necrosis Factor / blood Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/IL6R protein, human; 0/Interleukin-6; 0/Receptors, Interleukin-6; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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