Document Detail

The systemic effects of intermittent claudication are reversed by angioplasty.
MedLine Citation:
PMID:  11563891     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: exercise in patients with intermittent claudication causes systemic effects, the consequences of which are unknown. This study investigates whether successful PTA reverses the systemic effects. PATIENTS AND METHODS: ten patients with IC were recruited prior to PTA. Having emptied their bladders and rested for 1 h, pre-exercise blood and urine samples were collected. Patients underwent treadmill exercise to maximum walking time and blood samples were collected at 10, 20 and 30 min. A second urine sample was collected at 60 min. Total antioxidant capacity (TAC) and von Willebrands Factor (vWF) were measured in blood and albumin/creatinine ratio (ACR) and retinol binding protein/creatinine ratio (RBP/Cr) in urine. Patients were recalled 2 weeks after successful angioplasty and the protocol repeated. Following PTA patients walked for a maximum of 5 min. RESULTS: there was no significant change in vWF. Exercise in claudicants induced a significant increase in median ACR (pre/post exercise=0.85 p =0.03) and in median RBP/Cr (pre/post exercise=1.8 p =0.04). These changes were no longer evident after successful PTA. TAC was significantly different before and after angioplasty at all time intervals. CONCLUSION: successful PTA reverses glomerular effects of exercise in claudicants. Future work should investigate the use of PTA in conjunction with exercise in the treatment of peripheral vascular disease.
D R Lewis; A Day; J Y Jeremy; R N Baird; F C Smith; P M Lamont
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  22     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-20     Completed Date:  2001-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  326-30     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Limited.
University Department of Surgery, Bristol Royal Infirmary, Bristol, UK.
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MeSH Terms
Aged, 80 and over
Angioplasty, Balloon*
Antioxidants / metabolism
Creatinine / metabolism
Intermittent Claudication / metabolism*,  surgery
Middle Aged
Physical Exertion
Retinol-Binding Proteins / metabolism
Serum Albumin / metabolism
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Retinol-Binding Proteins; 0/Serum Albumin; 0/von Willebrand Factor; 60-27-5/Creatinine
Comment In:
Eur J Vasc Endovasc Surg. 2002 Jun;23(6):570-1   [PMID:  12146457 ]

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