| The systemic effects of intermittent claudication are reversed by angioplasty. | |
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MedLine Citation:
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PMID: 11563891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: exercise in patients with intermittent claudication causes systemic effects, the consequences of which are unknown. This study investigates whether successful PTA reverses the systemic effects. PATIENTS AND METHODS: ten patients with IC were recruited prior to PTA. Having emptied their bladders and rested for 1 h, pre-exercise blood and urine samples were collected. Patients underwent treadmill exercise to maximum walking time and blood samples were collected at 10, 20 and 30 min. A second urine sample was collected at 60 min. Total antioxidant capacity (TAC) and von Willebrands Factor (vWF) were measured in blood and albumin/creatinine ratio (ACR) and retinol binding protein/creatinine ratio (RBP/Cr) in urine. Patients were recalled 2 weeks after successful angioplasty and the protocol repeated. Following PTA patients walked for a maximum of 5 min. RESULTS: there was no significant change in vWF. Exercise in claudicants induced a significant increase in median ACR (pre/post exercise=0.85 p =0.03) and in median RBP/Cr (pre/post exercise=1.8 p =0.04). These changes were no longer evident after successful PTA. TAC was significantly different before and after angioplasty at all time intervals. CONCLUSION: successful PTA reverses glomerular effects of exercise in claudicants. Future work should investigate the use of PTA in conjunction with exercise in the treatment of peripheral vascular disease. |
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Authors:
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D R Lewis; A Day; J Y Jeremy; R N Baird; F C Smith; P M Lamont |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 22 ISSN: 1078-5884 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-09-20 Completed Date: 2001-10-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
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Languages: eng Pagination: 326-30 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Harcourt Publishers Limited. |
Affiliation:
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University Department of Surgery, Bristol Royal Infirmary, Bristol, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty, Balloon* Antioxidants / metabolism Creatinine / metabolism Female Humans Intermittent Claudication / metabolism*, surgery Male Middle Aged Physical Exertion Retinol-Binding Proteins / metabolism Serum Albumin / metabolism von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Retinol-Binding Proteins; 0/Serum Albumin; 0/von Willebrand Factor; 60-27-5/Creatinine |
| Comments/Corrections | |
Comment In:
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Eur J Vasc Endovasc Surg. 2002 Jun;23(6):570-1
[PMID:
12146457
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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