Document Detail

The systemic availability of meptazinol in man after oral and rectal doses.
MedLine Citation:
PMID:  2744068     Owner:  NLM     Status:  MEDLINE    
We have studied the pharmacokinetics of the centrally-acting analgesic meptazinol after oral and rectal administration to 15 healthy men. Each subject took a standard 200 mg tablet orally and Witepsol H12 suppositories containing 75, 100, and 150 mg of the drug in a cross-over design. Meptazinol plasma concentrations were measured by HPLC using fluorescence detection and the pharmacokinetics determined. The tmax values for the 100 mg and 150 mg suppositories (median = 0.5 h) were statistically significantly shorter than for the tablet (median = 1.13 h), suggesting that meptazinol was more rapidly absorbed via the rectal route. Despite substantial intersubject variation in Cmax the plasma concentrations after rectal dosage were higher than after oral administration. There was a statistically significant (p less than 0.001) improvement in systemic availability for each of the suppository doses (mean approximately 15.5% compared with the oral tablet (mean approximately 4.5%).
G R Murray; O Petitjean; R A Franklin; D F Graham; J H Trouvin; C Jacquot
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  36     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  279-82     Citation Subset:  IM    
Wyeth Laboratories, Taplow, Maidenhead, Berkshire, UK.
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MeSH Terms
Administration, Oral
Administration, Rectal
Azepines / pharmacokinetics*
Chromatography, High Pressure Liquid
Meptazinol / administration & dosage,  blood,  pharmacokinetics*
Random Allocation
Reg. No./Substance:
0/Azepines; 0/Suppositories; 54340-58-8/Meptazinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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