Document Detail

A systemic acceleratory phenomenon (SAP) accompanies the regional acceleratory phenomenon (RAP) during healing of a bone defect in the rat.
MedLine Citation:
PMID:  1858523     Owner:  NLM     Status:  MEDLINE    
The rate of remodeling in the region of a bone defect exceeds normal tissue activity. It was Frost who described this reaction as a regional acceleratory phenomenon (RAP). We investigated the local healing process with rats with a burr hole defect (1.2 mm in diameter) in the left tibia. We differentiated an initial phase of bone formation followed by a phase of predominant resorption. To determine whether this regional enhancement of bone formation would result in a systemic impact on bone metabolism, we analyzed both tibiae and femora and the fourth lumbar vertebra. On day 7 both femora of rats with the tibial defect showed a significant increase in computerized x-ray density, dry weight, ash weight, and Ca2+ content. Both tibiae and the fourth lumbar vertebra showed a significant increase in mineralizing surface, mineral apposition rate, and bone formation rate. Because of these results we conclude that a systemic acceleratory phenomenon (SAP) accompanies the RAP. SAP affects only the cancellous, but not the cortical bone compartment. SAP is associated closely with the occurrence of woven bone during the formation phase of the healing process. Thus we assume that woven bone formation plays a pivotal role in the mediation of SAP.
M Mueller; T Schilling; H W Minne; R Ziegler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  6     ISSN:  0884-0431     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-28     Completed Date:  1991-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-10     Citation Subset:  IM; S    
Department of Medicine I, Endocrinology, University of Heidelberg, Germany.
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MeSH Terms
Absorptiometry, Photon / methods
Bone Development / physiology*
Bone and Bones / injuries*,  radiography
Femur / radiography
Image Processing, Computer-Assisted
Rats, Inbred Strains
Spine / radiography
Tibia / radiography
Time Factors
Wound Healing / physiology

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