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A systematic review of the time course of atherosclerotic plaque regression.
MedLine Citation:
PMID:  24632041     Owner:  NLM     Status:  Publisher    
OBJECTIVE: We sought to determine the time required for lipid treatment to produce regression of atherosclerotic plaques.
BACKGROUND: The cholesterol content of atherosclerotic plaques contributes to their instability, and most acute cardiac events including myocardial infarction and sudden death are produced by coronary plaque disruption. We systematically reviewed the literature on atherosclerosis regression to identify the time required for cholesterol egress, plaque regression, and possible plaque stabilization. Such information may help decide when patients with statin side effects or other reasons for statin discontinuation could consider a reduction in the intensity of treatment.
METHODS: We performed a PubMed search to identify English language articles reporting atherosclerotic regression. Articles pertinent to the topic were reviewed in detail.
RESULTS: We identified 189 articles, 50 of which provided sufficient information to establish a rate of regression and 31 of which demonstrated plaque regression with statin therapy in the carotid (n = 11), coronary (n = 16), and aortic (n = 4) vascular beds. Plaque regression occurred after an average of 19.7 months of treatment.
CONCLUSION: Regression of atherosclerotic plaque using statin therapy in those studies documenting regression occurred after an average time of 19.7 months. This suggests that patients should undergo approximately two years of aggressive lipid reduction before considering a reduction of statin therapy.
Adam M Noyes; Paul D Thompson
Publication Detail:
Type:  REVIEW     Date:  2014-2-22
Journal Detail:
Title:  Atherosclerosis     Volume:  234     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  75-84     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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