| A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting. | |
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MedLine Citation:
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PMID: 16923604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To maximize the findings of animal experiments to inform likely health effects in humans, a thorough review and evaluation of the animal evidence is required. Systematic reviews and, where appropriate, meta-analyses have great potential in facilitating such an evaluation, making efficient use of the animal evidence while minimizing possible sources of bias. The extent to which systematic review and meta-analysis methods have been applied to evaluate animal experiments to inform human health is unknown. Using systematic review methods, we examine the extent and quality of systematic reviews and meta-analyses of in vivo animal experiments carried out to inform human health. We identified 103 articles meeting the inclusion criteria: 57 reported a systematic review, 29 a systematic review and a meta-analysis, and 17 reported a meta-analysis only. The use of these methods to evaluate animal evidence has increased over time. Although the reporting of systematic reviews is of adequate quality, the reporting of meta-analyses is poor. The inadequate reporting of meta-analyses observed here leads to questions on whether the most appropriate methods were used to maximize the use of the animal evidence to inform policy or decision-making. We recommend that guidelines proposed here be used to help improve the reporting of systematic reviews and meta-analyses of animal experiments. Further consideration of the use and methodological quality and reporting of such studies is needed. |
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Authors:
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Jaime L Peters; Alex J Sutton; David R Jones; Lesley Rushton; Keith R Abrams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes Volume: 41 ISSN: 0360-1234 ISO Abbreviation: J Environ Sci Health B Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-22 Completed Date: 2006-11-09 Revised Date: 2009-07-21 |
Medline Journal Info:
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Nlm Unique ID: 7607167 Medline TA: J Environ Sci Health B Country: United States |
Other Details:
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Languages: eng Pagination: 1245-58 Citation Subset: IM |
Affiliation:
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Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, UK. jlp9@leicester.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Experimentation* Animals Guidelines as Topic Humans Meta-Analysis as Topic* Research / standards* Research Design Review Literature as Topic* Terminology as Topic |
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