| A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base. | |
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MedLine Citation:
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PMID: 19921290 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chondrosarcoma (CSA) of the skull base (SB) is an uncommon, slowly growing, neoplasm comprising approximately 0.1% of all intracranial tumors and 6% of SB lesions. Even though its growth is slow, CSA is a potentially lethal tumor. The therapeutic approach to CSA of the SB is still controversial and clinical experience is limited because of the relative rarity of this tumor. The use of proton therapy (PT) after maximal surgery is widely accepted, but there are no controlled studies demonstrating the need of PT and its superiority in comparison to radiotherapy with photons. We conducted a systematic review of the scientific literature published during the period between January 1980 and June 2008 on data regarding irradiation of CSA of the SB with PT and a series of inclusion criteria. During August 2008, two independent reviewers (M.A. and D.A.), by applying the key words "skull base", "chondrosarcoma", and "proton therapy" selected those studies from the PubMed database in which a minimum of ten patients received palliative, radical, or postoperative irradiation with protons and which furnished a minimum of 24 months of follow-up. Forty nine reports were retrieved. There were no prospective trials (randomized or nonrandomized) but just nine uncontrolled single-arm studies for PT mainly related to advanced and frequently incompletely resected tumors. According to the inclusion criteria, only four articles, reporting the most recent updated results of the publishing institution, were included in the analysis providing clinical outcomes for 254 patients in total. Therapeutic approach to CSA of the SB has traditionally relied on surgical control. Radiation therapy has demonstrated to be a valuable modality for local control in the postoperative setting or in advanced/inoperable cases treated with definitive intent. The use of PT following maximal surgical resection shows a very high probability of medium- and long-term cure with a relatively low risk of significant complications. |
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Authors:
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Maurizio Amichetti; Dante Amelio; Marco Cianchetti; Riccardo Maurizi Enrici; Giuseppe Minniti |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-11-17 |
Journal Detail:
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Title: Neurosurgical review Volume: - ISSN: 1437-2320 ISO Abbreviation: - Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7908181 Medline TA: Neurosurg Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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ATreP, Agenzia Provinciale per la Protonterapia, Via F.lli Perini, 181, 38100, Trento, Italy, amichett@atrep.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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