| A systematic review of neuroimaging for cerebral palsy. | |
| | |
MedLine Citation:
|
PMID: 18263759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The American Academy of Neurology now recommends that all cases of cerebral palsy of unknown origin undergo neuroimaging. Controversy surrounds this recommendation because of concerns about the adequacy of the supporting evidence. This article reviews the evidence provided by magnetic resonance imaging (MRI) and computed tomography (CT) imaging studies in cerebral palsy and discusses the potential benefits of imaging, techniques in current use, and future directions, with a focus on improving etiologic understanding. Most (83%) children with cerebral palsy have abnormal neuroradiological findings, with white matter damage the most common abnormality. Combined gray and white matter abnormalities are more common among children with hemiplegia; isolated white matter abnormalities are more common with bilateral spasticity or athetosis, and with ataxia; isolated gray matter damage is the least common finding. About 10% of cerebral palsy is attributable to brain malformations, and 17% of cerebral palsy cases have no abnormality detectable by conventional MR or CT imaging. Although neuroimaging studies have increased our understanding of the abnormalities in brain development in cerebral palsy, they are less informative than they might be because of 4 common problems: (1) inappropriate assignment of etiology to morphologic findings, (2) inconsistent descriptions of radiologic findings, (3) uncertain relationship of pathologic findings to brain insult timing estimates, and (4) study designs that are not based on generalizable samples. Neuroimaging is not necessarily required for diagnosis of cerebral palsy because the disorder is based on clinical findings. The principal contribution of imaging is to the understanding of etiology and pathogenesis, including ruling in or out conditions that may have implications for genetic counseling, such as malformations. In the future, as more sophisticated imaging procedures are applied to cerebral palsy, specific morphologic findings may be linked to etiologic events or exposures, thus leading to potential pathways for prevention. |
| | |
Authors:
|
Steven J Korzeniewski; Gretchen Birbeck; Mark C DeLano; Michael J Potchen; Nigel Paneth |
Related Documents
:
|
8202989 - Magnetic resonance imaging assessment of evolving focal cerebral ischemia. comparison w... 14966159 - Comparative analysis of the spatial distribution and severity of cerebral microbleeds a... 21743079 - Evaluation of organ doses in ct examinations with an infant anthropomorphic phantom. 16585819 - Cerebral blood flow abnormalities in children with sydenham's chorea: a spect study. 12763349 - Dyke-davidoff-masson syndrome manifested by seizure in late childhood: a case report. 105309 - Physiologic changes in regional cerebral blood flow defined by xenon-enhanced ct scanning. 3588929 - Hemorrhagic intracranial malignant neoplasms: spin-echo mr imaging. 6246139 - Coexistence of pituitary adrenocorticotropin-dependent cushing's syndrome with a solita... 8028069 - Cholesteatoma: diagnosis and staging by ct scan. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Journal of child neurology Volume: 23 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-02-11 Completed Date: 2008-03-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
|
Languages: eng Pagination: 216-27 Citation Subset: IM |
Affiliation:
|
Department of Epidemiology, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA. stevek@epi.msu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Brain
/
pathology*,
radiography Brain Damage, Chronic / pathology Cerebral Palsy / classification, pathology*, radiography Diagnostic Techniques, Neurological* Humans Magnetic Resonance Imaging* Tomography, X-Ray Computed* |
| Grant Support | |
ID/Acronym/Agency:
|
T32 HD046477-01A1/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic and clinical heterogeneity in eIF2B-related disorder.
Next Document: Steroid-responsive chronic cerebellitis with positive glutamate receptor delta 2 antibody.