Document Detail

A systematic review of mercury ototoxicity.
MedLine Citation:
PMID:  22729255     Owner:  NLM     Status:  In-Data-Review    
Mercury is neurotoxic, and numerous studies have confirmed its ototoxic effect. However, the diagnosis and follow-up of mercury exposure require understanding the pathophysiology of the chemical substance. Based on a systematic literature review, this study aimed to demonstrate whether mercury is ototoxic and to analyze its mechanism of action on the peripheral and central auditory system, in order to contribute to the diagnosis and follow-up of exposure. This was a systematic review of studies published on the effects of mercury exposure on the auditory system. The full text of the studies and their methodological quality were analyzed. The review identified 108 studies published on the theme, of which 28 met the inclusion criteria. All the articles in the analysis showed that mercury exposure is ototoxic and produces peripheral and/or central damage. Acute and long-term exposure produces irreversible damage to the central auditory system. Biomarkers were unable to predict the relationship between degree of mercury poisoning and degree of lesion in the auditory system.
Ana Cristina Hiromi Hoshino; Heloisa Pacheco Ferreira; Olaf Malm; Renata Mamede Carvallo; Volney Magalhães Câmara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública     Volume:  28     ISSN:  1678-4464     ISO Abbreviation:  Cad Saude Publica     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8901573     Medline TA:  Cad Saude Publica     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1239-48     Citation Subset:  IM    
Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
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