Document Detail

A systematic review of the effect of paracetamol on blood pressure in hypertensive and non-hypertensive subjects.
MedLine Citation:
PMID:  23145789     Owner:  NLM     Status:  MEDLINE    
AIM: To review current evidence on the effect of paracetamol on blood pressure (BP), the quality of the previous studies and the validity of the results, and to summarize these findings.
METHODS: A systematic literature review was performed by searching PubMed, the Cochrane library and EMBASE for publications between the years 1963 and 2012.
RESULTS: We identified three case reports, seven prospective observational trials, six randomized controlled trials, one commentary and two reviews. Some, but not all, of the observational studies, which included over 147 000 patients, showed an increased risk of hypertension with paracetamol use. The randomized studies were generally small and the results were inconsistent. Three studies, which included 104 patients, showed an increase of systolic BP by ~4 mmHg, two studies, which included 27 patients, reported no change in BP and one study, which included 21 patients, reported a fall in BP although no placebo arm was included for comparison.
CONCLUSIONS: The overall effect of paracetamol on BP is unclear. Given that paracetamol is often suggested as a safer alternative to non-steroidal anti-inflammatory drugs (NSAIDs), it would seem that further prospective evidence is now needed to address the effect of paracetamol on BP. This would be best done with larger studies in relevant cohorts using BP measured by ambulatory BP monitoring as the primary endpoint.
Emma J Turtle; James W Dear; David J Webb
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-22     Completed Date:  2014-01-17     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1396-405     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Acetaminophen / adverse effects,  pharmacology*
Analgesics, Non-Narcotic / adverse effects,  pharmacology*
Blood Pressure / drug effects*
Hypertension / drug therapy*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 362O9ITL9D/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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